线上报告

报告一

报告题目：Introduction into structural biochemistry. The levels of protein structure. History of structural biology. X-ray analysis. Soluble and membrane proteins, crystallization difficulties. The beginning of the development of electron microscopy.

时间：2024年11月12日（周二），9:00-11:00

报告二

报告题目：The possibilities and application of electron microscopy in plant biology, the foundations of structural proteomics, comparison with other methods. Transmission electron microscope device. Diagram of the microcope. Different types of cathodes and lenses. Condenser. Stage. Vacuum system.

时间：2024年11月14日（周四），9:00-11:00

报告三

报告题目：Three-dimensional reconstruction: basic principles. Two-dimensional projections as the basis for a three-dimensional image. Two-dimensional and three-dimensional Fourier transform. Euler Sphere. Methods for constructing three-dimensional reconstruction: angular reconstitution, projection matching. Definition of permission for reconstruction; Factors affecting the reconstruction. Heterogeneity of particles. Three-dimensional classification.

时间：2024年11月26日（周二），16:30-20:30

报告四

报告题目：Structure of globular proteins. Protein domains consisting of alpha helices and beta sheets; Dps, albabetin, Ribosome; molecular basis of protein biosynthesis; protein folding; chaperonins, molecular basis of transcription; structures of polymerase and histones; chromatin remodeling factors

时间：2024年11月28日（周四），16:30-20:30

报告五

报告题目：Structure of fibrillar proteins. Cytoskeleton. Microtubules. Actin activators, inhibitors and bundlers. Formins, Arp2/3 complex. Mechanical strength.

时间：2024年12月3日（周二），16:30-20:30

报告六

报告题目：Purification of membrane proteins. Structure of membrane proteins. Ion channels; activation mechanisms, ligand-dependent channels: KATP channels link metabolism to electrical activity; Functional roles of ion channels, aquaporins; transporters, mechanosensitive channels; Transporters; differences between transporters and ion channels.

时间：2024年12月5日（周四），16:30-20:30

报告七

报告题目：Structure of photosynthetic apparatus. Proteins involved into photosynthesis. Light-harvesting complexes, Phycobilisomes.

时间：2024年12月10日（周二），16:30-20:30

报告八

报告题目：Structure of plant and bacterial viruses. DNA- and RNA-containing viruses; high-resolution structure acquisition; bacteriophages; different types of symmetry, difference between plant, bacterial and animal virues.

时间：2024年12月12日（周一），16:30-20:30

方式：通过腾讯会议远程视频讲座，链接https://meeting.tencent.com/dm/aLOnCz1hAAAI

腾讯会议：741-8361-4777

会议密码：150040

线下报告

报告一

报告题目：The similarity and difference of light and electron microscopes. Image formation, electron scattering by a sample; Methods for obtaining and registering images. Direct electron detectors. Preparation of samples for TEM. Ultrasections. Cryo substitution. Grids for samples. Negative contrast. Cryo microscopy.

时间：2024年11月19日（周二），9:00-11:00

报告二

报告题目：History of single particle EM. Particle collection: manual and semi-automatic; A review of particle collection programs. Primary processing of electron microscopic images. Image quality. Classification of electron microscopic images. Signal to noise ratio. Analysis factors; Particle alignment; Basics of multivariate statistical analysis. Hierarchical classification; Multi-reference classification. Permission and criteria for its evaluation. Radiation damage. Focus; Aberrations and their effect on image quality. Contrast. Ways to increase contrast.

时间：2024年11月20日（周三），9:00-11:00

地点：东北林业大学逸夫实验楼315会议室

报告人：Sokolova Olga教授，深圳北理莫斯科大学教授

报告人简介：

Sokolova Olga教授于1987年在皮洛耶夫医学院获得学士学位，并分别于1996年和2012年先后获得生理学和生物物理学博士，自2020年后任深圳北理莫斯科大学教授。她的科研方向包括生物物理学、结构生物学、纳米生物技术及冷冻电镜的应用。Sokolova Olga教授曾获简·科芬查尔兹和奥格龙博士后奖学金，MSU发展计划竞赛一等奖等诸多奖励。近十年来，Sokolova Olga教授在PNAS，Nature communications，Biomedicines，Communications Biology等高水平期刊发表诸多研究成果。

欢迎各位老师和同学积极参加!